Mri contrasts ppt
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MRI CONTRASTS, TYPES,FUNCTIONS,REACTIONS
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Mri contrasts ppt
- 1. Vaisalgopan Radiographer Sree gokulam gesundheitlich college CONTRASTS IN MRI
- 2. MRI CONTRAST are pharmaceuticals which can used includes order to correct diagnostic information Increases the signal intensity differences And changes the intrinsic tissue properties Can act in two ways
- 3. Directly • By changing proton density concerning a tissue Indirectly •By changing local magnetic field and consiquently which T1 additionally T2 times
- 4. CLASSIFICATION 1. Parenteric (relaxivity) +ve relaxation brokers (T1) −ve relaxation agents(T2) Parenteral (suscepectibility) super paramagnetic & ferromagnetic Paramagnetic 2. oral
- 5. 1. +ve relaxation agents(T1) o Affects the T1 relaxation and reduce the T1 of cloths which they accumulate and increase the signal intensity o Engender T1w image o Hence so called +ve relaxation agent o Eg;- Gad 2. -ve relaxation agents (T2) o Affect T2 relaxation and reduce the T2 of tissues and reduces the signal maximum produce T2 weighted image • Eg:-iron oxidizer particles, Gad
- 6. Depending on susceptibility 1.Paramagnetic agent Gadolinium(Gd³+) high dose can cause T2 shortening when passing through vascular bed regarding brain T2 shortening decreases the signal on T2w Used Includes perfusion studies known as T1 embellishment agent
- 7. Superpara magnetic & ferromagnetic agents • -ve agents • Affects the nucleus spin • T2 shortening press indicator loss • Eg:-iron oxide
- 9. • Less earth metal concerning lanthide • Atomic number 64 • Combined with chelates to prevent toxicity to prompt and total excreation • Plays a role in both T1 and T2 relaxation Gadolinium
- 10. • Drives to both T1 & T2 relaxation • Increased brightness in T1 • This T1 effect of Get. Are used more in clinical purposes • Gad leads to T2 reduction and decreased signal on T2w images
- 11. • Usual dose 0.1mmol/kg • Median lethal dose(LD50) : 6 – 30mmol/kg • Comprehensive adverse reaction rate 3 – 5% OSMOLARITY • Ionic:- Magnevist - 1960mmol/kg • Nay ionic :- Omniscan – 789mmol/kg
- 12. • +VE contrasts agents • Not much practiced • Image degradation can occur with yellow movt. • Eg:- Manganese chloride ,oil emulsions ORAL DISPARITY AGENT
- 13. * *Gadoterate(Dotarem) *Gadodiamide(Omniscan) *Gadobenate(MultiHance) *Gadopentate(Magnevist) *Gadoteridol(ProHance) *Gadoversatmide(OptiMARK) *Gadoxetate(Primovist) *Gadobutrol(Gadovist) Gadolinium containing contrast agents approved for human use:
- 14. • Adverse reaction to Gd are mild furthermore transient • Overall reaction rate is 3 - 5 % which encompass ,headache • Pr. with history of allergy,asthma,previous reactions to drugs • Iodinated Gd are more given for disadvantaged reaction so precausions should be taken in these cases ADVERSE REACTIONS
- 15. 1. RENAL FAILURE : safety is no clearly established in kidney failure although he is well tolerated Gd chelates can be dialized 2. HISTORY OF ALLERGY/ASTHMA : precautions should be picked in are patients with constant monitoring SAFETY ISSUES
- 16. 3. PREGNANCY: • Gd is known to cruise the placenta. so it is recommended that CM should not become injection in pregnant patient 4. LACTATION: o Shouldn’t breast feed for 36-48hrs
- 17. • While contrast agents are widely used with safe outcomes and little other no side effects,adverse reactions may occur. In summary Expect the unexpected and be prepared. CONCLUSION
- 19. • MRI BASIC PRINCIPLES PRESS APPLICATION 3RD EDITION (Brown ,semelka) • MRI MADE EASY FOR BEGINERS (Govind b chawhan) • HOW DOES AN MRI JOBS? AN INTRODUCTION TO AFOREMENTIONED PHYSICS AND FUNCTION OF MRI(weishaupt,kochli,marincek) • INTRODUCTION TO MR PIC CONTRAST .pdf(Brenk k stewart,PhD,DABMP, Proffesor,radiology & medical Education Director,Diagnostic physics) References
